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Selected Peer-reviewed publications (Sorted by newest to oldest):

Lloyd, B. A., Han, Y., Roth, R., Zhang, B., & Aoto, J. (2023). Neurexin-3 subsynaptic densities are spatially distinct from Neurexin-1 and essential for excitatory synapse nanoscale organization in the hippocampus. Nature communications, 14(1), 4706.

Boxer, E. E.*, Kim, J.*, Dunn, B., & Aoto, J. (2023). Ventral Subiculum Inputs to Nucleus Accumbens Medial Shell Preferentially Innervate D2R Medium Spiny Neurons and Contain Calcium Permeable AMPARs. The Journal of neuroscience : the official journal of the Society for Neuroscience, 43(7), 1166–1177.

*Equal Contribution

Boxer, E. E., & Aoto, J. (2022). Neurexins and their ligands at inhibitory synapses. Frontiers in synaptic neuroscience, 14, 1087238.


Boxer, E. E., Seng, C., Lukacsovich, D., Kim, J., Schwartz, S., Kennedy, M. J., Földy, C., & Aoto, J. (2021). Neurexin-3 defines synapse- and sex-dependent diversity of GABAergic inhibition in ventral subiculum. Cell reports, 37(10), 110098.

Cai, Y., Nielsen, B. E., Boxer, E. E., Aoto, J., & Ford, C. P. (2021). Loss of nigral excitation of cholinergic interneurons contributes to parkinsonian motor impairments. Neuron, 109(7), 1137–1149.e5.

Restrepo, S., Schwartz, S. L., Kennedy, M. J., & Aoto, J. (2020). Measuring Transcellular Interactions through Protein Aggregation in a Heterologous Cell System. Journal of visualized experiments : JoVE, (159), 10.3791/61237.

Restrepo, S., Langer, N. J., Nelson, K. A., & Aoto, J. (2019). Modeling a Neurexin-3α Human Mutation in Mouse Neurons Identifies a Novel Role in the Regulation of Transsynaptic Signaling and Neurotransmitter Release at Excitatory Synapses. The Journal of neuroscience : the official journal of the Society for Neuroscience, 39(46), 9065–9082.

Dai, J., Aoto, J., & Südhof, T. C. (2019). Alternative Splicing of Presynaptic Neurexins Differentially Controls Postsynaptic NMDA and AMPA Receptor Responses. Neuron, 102(5), 993–1008.e5.

Liu, Q., Sinnen, B. L., Boxer, E. E., Schneider, M. W., Grybko, M. J., Buchta, W. C., Gibson, E. S., Wysoczynski, C. L., Ford, C. P., Gottschalk, A., Aoto, J., Tucker, C. L., & Kennedy, M. J. (2019). A Photoactivatable Botulinum Neurotoxin for Inducible Control of Neurotransmission. Neuron, 101(5), 863–875.e6.

Purkey, A. M., Woolfrey, K. M., Crosby, K. C., Stich, D. G., Chick, W. S., Aoto, J., & Dell'Acqua, M. L. (2018). AKAP150 Palmitoylation Regulates Synaptic Incorporation of Ca2+-Permeable AMPA Receptors to Control LTP. Cell reports, 25(4), 974–987.e4.


Földy, C., Darmanis, S., Aoto, J., Malenka, R. C., Quake, S. R., & Südhof, T. C. (2016). Single-cell RNAseq reveals cell adhesion molecule profiles in electrophysiologically defined neurons. Proceedings of the National Academy of Sciences of the United States of America, 113(35), E5222–E5231.


Chanda, S., Aoto, J., Lee, S. J., Wernig, M., & Südhof, T. C. (2016). Pathogenic mechanism of an autism-associated neuroligin mutation involves altered AMPA-receptor trafficking. Molecular psychiatry, 21(2), 169–177.

Pak, C., Danko, T., Zhang, Y., Aoto, J., Anderson, G., Maxeiner, S., Yi, F., Wernig, M., & Südhof, T. C. (2015). Human Neuropsychiatric Disease Modeling using Conditional Deletion Reveals Synaptic Transmission Defects Caused by Heterozygous Mutations in NRXN1. Cell stem cell, 17(3), 316–328.

Anderson, G. R., Aoto, J., Tabuchi, K., Földy, C., Covy, J., Yee, A. X., Wu, D., Lee, S. J., Chen, L., Malenka, R. C., & Südhof, T. C. (2015). β-Neurexins Control Neural Circuits by Regulating Synaptic Endocannabinoid Signaling. Cell, 162(3), 593–606.

Aoto, J., Földy, C., Ilcus, S. M., Tabuchi, K., & Südhof, T. C. (2015). Distinct circuit-dependent functions of presynaptic neurexin-3 at GABAergic and glutamatergic synapses. Nature neuroscience, 18(7), 997–1007.

Aoto, J., Martinelli, D. C., Malenka, R. C., Tabuchi, K., & Südhof, T. C. (2013). Presynaptic neurexin-3 alternative splicing trans-synaptically controls postsynaptic AMPA receptor trafficking. Cell, 154(1), 75–88.

Anderson, G. R., Galfin, T., Xu, W., Aoto, J., Malenka, R. C., & Südhof, T. C. (2012). Candidate autism gene screen identifies critical role for cell-adhesion molecule CASPR2 in dendritic arborization and spine development. Proceedings of the National Academy of Sciences of the United States of America, 109(44), 18120–18125.

Sarti, F., Schroeder, J., Aoto, J., & Chen, L. (2012). Conditional RARα knockout mice reveal acute requirement for retinoic acid and RARα in homeostatic plasticity. Frontiers in molecular neuroscience, 5, 16.


Aoto, J.*, Nam, C. I.*, Poon, M. M.*, Ting, P., & Chen, L. (2008). Synaptic signaling by all-trans retinoic acid in homeostatic synaptic plasticity. Neuron, 60(2), 308–320.

*Equal Contribution


Maghsoodi, B., Poon, M. M., Nam, C. I., Aoto, J., Ting, P., & Chen, L. (2008). Retinoic acid regulates RARalpha-mediated control of translation in dendritic RNA granules during homeostatic synaptic plasticity. Proceedings of the National Academy of Sciences of the United States of America, 105(41), 16015–16020.

Aoto, J., Ting, P., Maghsoodi, B., Xu, N., Henkemeyer, M., & Chen, L. (2007). Postsynaptic ephrinB3 promotes shaft glutamatergic synapse formation. The Journal of neuroscience : the official journal of the Society for Neuroscience, 27(28), 7508–7519.

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