Publications
Selected Peer-reviewed publications (Sorted by newest to oldest):
Lloyd, B. A., Han, Y., Roth, R., Zhang, B., & Aoto, J. (2023). Neurexin-3 subsynaptic densities are spatially distinct from Neurexin-1 and essential for excitatory synapse nanoscale organization in the hippocampus. Nature communications, 14(1), 4706. https://doi.org/10.1038/s41467-023-40419-2
Boxer, E. E.*, Kim, J.*, Dunn, B., & Aoto, J. (2023). Ventral Subiculum Inputs to Nucleus Accumbens Medial Shell Preferentially Innervate D2R Medium Spiny Neurons and Contain Calcium Permeable AMPARs. The Journal of neuroscience : the official journal of the Society for Neuroscience, 43(7), 1166–1177. https://doi.org/10.1523/JNEUROSCI.1907-22.2022
*Equal Contribution
Boxer, E. E., & Aoto, J. (2022). Neurexins and their ligands at inhibitory synapses. Frontiers in synaptic neuroscience, 14, 1087238. https://doi.org/10.3389/fnsyn.2022.1087238
Boxer, E. E., Seng, C., Lukacsovich, D., Kim, J., Schwartz, S., Kennedy, M. J., Földy, C., & Aoto, J. (2021). Neurexin-3 defines synapse- and sex-dependent diversity of GABAergic inhibition in ventral subiculum. Cell reports, 37(10), 110098. https://doi.org/10.1016/j.celrep.2021.110098
Cai, Y., Nielsen, B. E., Boxer, E. E., Aoto, J., & Ford, C. P. (2021). Loss of nigral excitation of cholinergic interneurons contributes to parkinsonian motor impairments. Neuron, 109(7), 1137–1149.e5. https://doi.org/10.1016/j.neuron.2021.01.028
Restrepo, S., Schwartz, S. L., Kennedy, M. J., & Aoto, J. (2020). Measuring Transcellular Interactions through Protein Aggregation in a Heterologous Cell System. Journal of visualized experiments : JoVE, (159), 10.3791/61237. https://doi.org/10.3791/61237
Restrepo, S., Langer, N. J., Nelson, K. A., & Aoto, J. (2019). Modeling a Neurexin-3α Human Mutation in Mouse Neurons Identifies a Novel Role in the Regulation of Transsynaptic Signaling and Neurotransmitter Release at Excitatory Synapses. The Journal of neuroscience : the official journal of the Society for Neuroscience, 39(46), 9065–9082. https://doi.org/10.1523/JNEUROSCI.1261-19.2019
Dai, J., Aoto, J., & Südhof, T. C. (2019). Alternative Splicing of Presynaptic Neurexins Differentially Controls Postsynaptic NMDA and AMPA Receptor Responses. Neuron, 102(5), 993–1008.e5. https://doi.org/10.1016/j.neuron.2019.03.032
Liu, Q., Sinnen, B. L., Boxer, E. E., Schneider, M. W., Grybko, M. J., Buchta, W. C., Gibson, E. S., Wysoczynski, C. L., Ford, C. P., Gottschalk, A., Aoto, J., Tucker, C. L., & Kennedy, M. J. (2019). A Photoactivatable Botulinum Neurotoxin for Inducible Control of Neurotransmission. Neuron, 101(5), 863–875.e6. https://doi.org/10.1016/j.neuron.2019.01.002
Purkey, A. M., Woolfrey, K. M., Crosby, K. C., Stich, D. G., Chick, W. S., Aoto, J., & Dell'Acqua, M. L. (2018). AKAP150 Palmitoylation Regulates Synaptic Incorporation of Ca2+-Permeable AMPA Receptors to Control LTP. Cell reports, 25(4), 974–987.e4. https://doi.org/10.1016/j.celrep.2018.09.085
Földy, C., Darmanis, S., Aoto, J., Malenka, R. C., Quake, S. R., & Südhof, T. C. (2016). Single-cell RNAseq reveals cell adhesion molecule profiles in electrophysiologically defined neurons. Proceedings of the National Academy of Sciences of the United States of America, 113(35), E5222–E5231. https://doi.org/10.1073/pnas.1610155113
Chanda, S., Aoto, J., Lee, S. J., Wernig, M., & Südhof, T. C. (2016). Pathogenic mechanism of an autism-associated neuroligin mutation involves altered AMPA-receptor trafficking. Molecular psychiatry, 21(2), 169–177. https://doi.org/10.1038/mp.2015.20
Pak, C., Danko, T., Zhang, Y., Aoto, J., Anderson, G., Maxeiner, S., Yi, F., Wernig, M., & Südhof, T. C. (2015). Human Neuropsychiatric Disease Modeling using Conditional Deletion Reveals Synaptic Transmission Defects Caused by Heterozygous Mutations in NRXN1. Cell stem cell, 17(3), 316–328. https://doi.org/10.1016/j.stem.2015.07.017
Anderson, G. R., Aoto, J., Tabuchi, K., Földy, C., Covy, J., Yee, A. X., Wu, D., Lee, S. J., Chen, L., Malenka, R. C., & Südhof, T. C. (2015). β-Neurexins Control Neural Circuits by Regulating Synaptic Endocannabinoid Signaling. Cell, 162(3), 593–606. https://doi.org/10.1016/j.cell.2015.06.056
Aoto, J., Földy, C., Ilcus, S. M., Tabuchi, K., & Südhof, T. C. (2015). Distinct circuit-dependent functions of presynaptic neurexin-3 at GABAergic and glutamatergic synapses. Nature neuroscience, 18(7), 997–1007. https://doi.org/10.1038/nn.4037
Aoto, J., Martinelli, D. C., Malenka, R. C., Tabuchi, K., & Südhof, T. C. (2013). Presynaptic neurexin-3 alternative splicing trans-synaptically controls postsynaptic AMPA receptor trafficking. Cell, 154(1), 75–88. https://doi.org/10.1016/j.cell.2013.05.060
Anderson, G. R., Galfin, T., Xu, W., Aoto, J., Malenka, R. C., & Südhof, T. C. (2012). Candidate autism gene screen identifies critical role for cell-adhesion molecule CASPR2 in dendritic arborization and spine development. Proceedings of the National Academy of Sciences of the United States of America, 109(44), 18120–18125. https://doi.org/10.1073/pnas.1216398109
Sarti, F., Schroeder, J., Aoto, J., & Chen, L. (2012). Conditional RARα knockout mice reveal acute requirement for retinoic acid and RARα in homeostatic plasticity. Frontiers in molecular neuroscience, 5, 16. https://doi.org/10.3389/fnmol.2012.00016
Aoto, J.*, Nam, C. I.*, Poon, M. M.*, Ting, P., & Chen, L. (2008). Synaptic signaling by all-trans retinoic acid in homeostatic synaptic plasticity. Neuron, 60(2), 308–320. https://doi.org/10.1016/j.neuron.2008.08.012
*Equal Contribution
Maghsoodi, B., Poon, M. M., Nam, C. I., Aoto, J., Ting, P., & Chen, L. (2008). Retinoic acid regulates RARalpha-mediated control of translation in dendritic RNA granules during homeostatic synaptic plasticity. Proceedings of the National Academy of Sciences of the United States of America, 105(41), 16015–16020. https://doi.org/10.1073/pnas.0804801105
Aoto, J., Ting, P., Maghsoodi, B., Xu, N., Henkemeyer, M., & Chen, L. (2007). Postsynaptic ephrinB3 promotes shaft glutamatergic synapse formation. The Journal of neuroscience : the official journal of the Society for Neuroscience, 27(28), 7508–7519. https://doi.org/10.1523/JNEUROSCI.0705-07.2007