Publications
Selected Peer-reviewed publications (Sorted by newest to oldest):
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Lloyd, B. A., Han, Y., Roth, R., Zhang, B., & Aoto, J. (2023). Neurexin-3 subsynaptic densities are spatially distinct from Neurexin-1 and essential for excitatory synapse nanoscale organization in the hippocampus. Nature communications, 14(1), 4706. https://doi.org/10.1038/s41467-023-40419-2
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Boxer, E. E.*, Kim, J.*, Dunn, B., & Aoto, J. (2023). Ventral Subiculum Inputs to Nucleus Accumbens Medial Shell Preferentially Innervate D2R Medium Spiny Neurons and Contain Calcium Permeable AMPARs. The Journal of neuroscience : the official journal of the Society for Neuroscience, 43(7), 1166–1177. https://doi.org/10.1523/JNEUROSCI.1907-22.2022
*Equal Contribution
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Boxer, E. E., & Aoto, J. (2022). Neurexins and their ligands at inhibitory synapses. Frontiers in synaptic neuroscience, 14, 1087238. https://doi.org/10.3389/fnsyn.2022.1087238
Boxer, E. E., Seng, C., Lukacsovich, D., Kim, J., Schwartz, S., Kennedy, M. J., Földy, C., & Aoto, J. (2021). Neurexin-3 defines synapse- and sex-dependent diversity of GABAergic inhibition in ventral subiculum. Cell reports, 37(10), 110098. https://doi.org/10.1016/j.celrep.2021.110098
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Cai, Y., Nielsen, B. E., Boxer, E. E., Aoto, J., & Ford, C. P. (2021). Loss of nigral excitation of cholinergic interneurons contributes to parkinsonian motor impairments. Neuron, 109(7), 1137–1149.e5. https://doi.org/10.1016/j.neuron.2021.01.028
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Restrepo, S., Schwartz, S. L., Kennedy, M. J., & Aoto, J. (2020). Measuring Transcellular Interactions through Protein Aggregation in a Heterologous Cell System. Journal of visualized experiments : JoVE, (159), 10.3791/61237. https://doi.org/10.3791/61237
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Restrepo, S., Langer, N. J., Nelson, K. A., & Aoto, J. (2019). Modeling a Neurexin-3α Human Mutation in Mouse Neurons Identifies a Novel Role in the Regulation of Transsynaptic Signaling and Neurotransmitter Release at Excitatory Synapses. The Journal of neuroscience : the official journal of the Society for Neuroscience, 39(46), 9065–9082. https://doi.org/10.1523/JNEUROSCI.1261-19.2019
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Dai, J., Aoto, J., & Südhof, T. C. (2019). Alternative Splicing of Presynaptic Neurexins Differentially Controls Postsynaptic NMDA and AMPA Receptor Responses. Neuron, 102(5), 993–1008.e5. https://doi.org/10.1016/j.neuron.2019.03.032
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Liu, Q., Sinnen, B. L., Boxer, E. E., Schneider, M. W., Grybko, M. J., Buchta, W. C., Gibson, E. S., Wysoczynski, C. L., Ford, C. P., Gottschalk, A., Aoto, J., Tucker, C. L., & Kennedy, M. J. (2019). A Photoactivatable Botulinum Neurotoxin for Inducible Control of Neurotransmission. Neuron, 101(5), 863–875.e6. https://doi.org/10.1016/j.neuron.2019.01.002
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Purkey, A. M., Woolfrey, K. M., Crosby, K. C., Stich, D. G., Chick, W. S., Aoto, J., & Dell'Acqua, M. L. (2018). AKAP150 Palmitoylation Regulates Synaptic Incorporation of Ca2+-Permeable AMPA Receptors to Control LTP. Cell reports, 25(4), 974–987.e4. https://doi.org/10.1016/j.celrep.2018.09.085
Földy, C., Darmanis, S., Aoto, J., Malenka, R. C., Quake, S. R., & Südhof, T. C. (2016). Single-cell RNAseq reveals cell adhesion molecule profiles in electrophysiologically defined neurons. Proceedings of the National Academy of Sciences of the United States of America, 113(35), E5222–E5231. https://doi.org/10.1073/pnas.1610155113
Chanda, S., Aoto, J., Lee, S. J., Wernig, M., & Südhof, T. C. (2016). Pathogenic mechanism of an autism-associated neuroligin mutation involves altered AMPA-receptor trafficking. Molecular psychiatry, 21(2), 169–177. https://doi.org/10.1038/mp.2015.20
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Pak, C., Danko, T., Zhang, Y., Aoto, J., Anderson, G., Maxeiner, S., Yi, F., Wernig, M., & Südhof, T. C. (2015). Human Neuropsychiatric Disease Modeling using Conditional Deletion Reveals Synaptic Transmission Defects Caused by Heterozygous Mutations in NRXN1. Cell stem cell, 17(3), 316–328. https://doi.org/10.1016/j.stem.2015.07.017
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Anderson, G. R., Aoto, J., Tabuchi, K., Földy, C., Covy, J., Yee, A. X., Wu, D., Lee, S. J., Chen, L., Malenka, R. C., & Südhof, T. C. (2015). β-Neurexins Control Neural Circuits by Regulating Synaptic Endocannabinoid Signaling. Cell, 162(3), 593–606. https://doi.org/10.1016/j.cell.2015.06.056
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Aoto, J., Földy, C., Ilcus, S. M., Tabuchi, K., & Südhof, T. C. (2015). Distinct circuit-dependent functions of presynaptic neurexin-3 at GABAergic and glutamatergic synapses. Nature neuroscience, 18(7), 997–1007. https://doi.org/10.1038/nn.4037
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Aoto, J., Martinelli, D. C., Malenka, R. C., Tabuchi, K., & Südhof, T. C. (2013). Presynaptic neurexin-3 alternative splicing trans-synaptically controls postsynaptic AMPA receptor trafficking. Cell, 154(1), 75–88. https://doi.org/10.1016/j.cell.2013.05.060
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Anderson, G. R., Galfin, T., Xu, W., Aoto, J., Malenka, R. C., & Südhof, T. C. (2012). Candidate autism gene screen identifies critical role for cell-adhesion molecule CASPR2 in dendritic arborization and spine development. Proceedings of the National Academy of Sciences of the United States of America, 109(44), 18120–18125. https://doi.org/10.1073/pnas.1216398109
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Sarti, F., Schroeder, J., Aoto, J., & Chen, L. (2012). Conditional RARα knockout mice reveal acute requirement for retinoic acid and RARα in homeostatic plasticity. Frontiers in molecular neuroscience, 5, 16. https://doi.org/10.3389/fnmol.2012.00016
Aoto, J.*, Nam, C. I.*, Poon, M. M.*, Ting, P., & Chen, L. (2008). Synaptic signaling by all-trans retinoic acid in homeostatic synaptic plasticity. Neuron, 60(2), 308–320. https://doi.org/10.1016/j.neuron.2008.08.012
*Equal Contribution
Maghsoodi, B., Poon, M. M., Nam, C. I., Aoto, J., Ting, P., & Chen, L. (2008). Retinoic acid regulates RARalpha-mediated control of translation in dendritic RNA granules during homeostatic synaptic plasticity. Proceedings of the National Academy of Sciences of the United States of America, 105(41), 16015–16020. https://doi.org/10.1073/pnas.0804801105
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Aoto, J., Ting, P., Maghsoodi, B., Xu, N., Henkemeyer, M., & Chen, L. (2007). Postsynaptic ephrinB3 promotes shaft glutamatergic synapse formation. The Journal of neuroscience : the official journal of the Society for Neuroscience, 27(28), 7508–7519. https://doi.org/10.1523/JNEUROSCI.0705-07.2007
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